Isabella of Spain

Isabella of Spain, also known as Isabella I, was the Queen of Castile and León from 1474 until her death in 1504. She is best remembered for her pivotal role in the unification of Spain and her support of Christopher Columbus's voyages to the New World. Her marriage to Emanuel I of Portugal significantly impacted the Jewish community in Portugal, as it resulted in a marriage contract that mandated the expulsion of 'heretics,' leading to violent repercussions, including the Lisbon Massacre of 1506.